The experimental conditions required to perform quantitative NMR spectroscopy are well-known. Performing quantitative NMR of polymers we have been asking two questions:

a) What are the precision and accuracy of the quantification by NMR? Signal-to-noise ratio and baseline correction can both play a critical role.

b) How does the polymer solubility determined by NMR compare to the one determined by other methods? What does this solubility correspond to?

References:

[1] Assessment of the extent of starch dissolution in dimethyl sulfoxide by 1H NMR spectroscopy. Schmitz S, Dona AC, Castignolles P, Gilbert RG, Gaborieau M, Macromolecular Bioscience 2009, 9, 506-14.

[2] Detection and quantification of branching in polyacrylates by size-exclusion chromatography (SEC) and melt-state 13C NMR spectroscopy. Castignolles P, Graf R, Parkinson M, Wilhelm M, Gaborieau M, Polymer 2009, 50, 2373-83.

[3] Towards a less biased dissolution of chitosan. Thevarajah JJ, Bulanadi JC, Wagner M, Gaborieau M, Castignolles P, Analytica Chimica Acta 2016, 935, 258-68.

[4] Assessment of the branching quantification in poly(acrylic acid): Is it as easy as it seems? Maniego AR, Sutton AT, Gaborieau M, Castignolles P, Macromolecules 2017, 50, 9032-41.

[5] Characterization of oligo(acrylic acid)s and their block co-oligomers. Sutton AT, Arrua RD, Gaborieau M, Castignolles P, Hilder EF, Analytica Chimica Acta 2018,1032,163-77.